Scientific Publications

Role of inflammation in atherosclerosis and MACE


  • Inflammation in Atherosclerosis: Some Thoughts About Acute Coronary Syndromes, Lucas et al., Circulation 2006; 113:728-732. Read More

  • Inflammation and Atherosclerosis. Novel Insights into Plaque Formation and Destabilization, Stoll et al., Stroke 2006; 27 (7): 1923-32. Read More>
  • Atherothrombosis and High-Risk Plaque: Part I: Evolving Concepts, Fuster et al., J. Am. Coll. Cardiol. 2005; 46: 937-954. Read More

  • Inflammation, Atherosclerosis, and Coronary Artery Disease, Hansson, G.K., N. Engl. J. Med. 2005; 253:1685-1695. Read More

  • Extracranial Thrombotically Active Carotid Plaque as a Risk Factor for Ischemic Stroke, Spagnoli et al., JAMA, 2004;292(15):1845-1852. Read More

  • From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part 1, Naghavi et al., Circulation 2003; 108: 1664-1672. Read More

  • Inflammation and Atherosclerosis, Libby et al., Circulation 2002; 105: 1135-1143. Read More

  • Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology, van der Wal et al., Circulation 1994; 89 (1): 36-44. Read More

Role of 5-LO in atherosclerosis and MACE


  • Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability, Qui et al., PNAS 2006; 103(21): 8161-8166. Read More

  • Association Between 5-Lipoxygenase Expression and Plaque Instability in Humans, Cipollone et al., Arterioscler Thromb Vasc Biol 2005; 25: 1665-1670. Read More

  • From Asthma to Atherosclerosis – 5 Lipoxygenase, Leukotrienes, and Inflammation, De Caterina et al., N Engl J Med 2004; 350(1): 4-7. Read More

  • Leukotrienes and atherosclerosis: new roles for old mediators, Jala et al., Trends in Immun 2004; 25(6): 315-322. Read More

  • Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis, Spanbroek et al., PNAS 2003; 100 (3): 1238-1243. Read More

  • Leukotriene B4 Receptor Antagonism Reduces Monocytic Foam Cells in Mice, Aiello et al., Aterioscler Thromb Vasc Biol. 2002; 22:443-449. Read More

  • Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene, Chen et al., Nature 1994; 372: 179-182. Read More

Clinical trial design


  • Increased activity of the ubiquitin-proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque, Marfella et al., JACC 2006; 47(12): 2444-55. Read More

  • Clinical relevance of C-Reactive Protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to-Zocor trial, Morrow et al., Circulation 2006; 114: 281-288. Read More

  • C-Reactive Protein levels and outcomes after statin therapy, Greenland et al., N Engl J Med 2005; 352(1): 20-28. Read More

  • Suppression of the functionally coupled Cyclooxygenase-2/Prostaglandin E Synthase as a basis of simvastatin-dependent plaque stabilization in humans, Cipollone et al, Circulation 2003; 107:1479-1485. Read More

Imaging


  • Accuracy of 64-slice computed tomography to classify and quantify plaque volumes in the proximal coronary system, Leber et al., JACC 2006; 47 (3): 672-677. Read More

  • Computer-aided detection and evaluation of lipid-rich plaque on noncontrast cardiac CT, AJR 2006; 186: S407-S413. Read More

  • Evaluation by multislice computed tomography of atherosclerotic coronary artery plaques in non-culprit, remote coronary arteries of patients with acute coronary syndromes, Kunimasa et al., Circulation 2005; 69: 1346-1351. Read More

  • Multidetector-row computed tomography of the coronary arteries: predictive value and quantitative assessment of non-calcified vessel-wall changes, Nikolaou et al., Eur Radiol 2003; 13: 2505-2512. Read More

  • In-vivo 18 F-fluorodeoxyglucose Positron Emission Tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients, Tawakol et al., JACC 2006; 48: 1818-1824. Read More>

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